Eric J. Hall, D.Phil., D.Sc., F.A.C.R., F.R.C.R., FASTRO

Contact Information

Eric J. Hall
Center for Radiological Research
VC 11-230
630 W. 168th St.
New York, NY 10032

Tel: (212) 305-5660
Fax: (212) 305-3229
email: ejh1@columbia.edu

Research Interests

  • Radiation induced carcinogenesis

  • Effects of neutrons, alpha particles and HZE particles

  • Health hazards of radon exposure

  • Hazards of space radiations

  • Low dose-rate radiobiology as it applies to brachytherapy

     Academic Training  
 

 

Undergraduate:

  • B.Sc., University College, London, U.K., 1953

 

Graduate:

  • D.Phil, Radiobiology, Oriel College, Oxford University, Oxford, U.K., 1962

  • M.A., Honoris Causa, Oriel College, Oxford University, Oxford, U.K., 1966

  • D.Sc., Honoris Causa, Oriel College, Oxford University, Oxford, U.K., 1977

  • Fellow of the American College of Radiology, 1981

  • Fellow of the Royal College of Radiology, 1999

  • Fellow of the Society of Radiological Protection, 2004

  • Fellow of the American Society of Therapeutic Radiology, 2006

 

   Current Academic and Professional Appointments  

  • Higgins Professor of Radiation Biophysics, College of Physicians & Surgeons of Columbia University

  • Professor of Radiation Oncology and Radiology, College of Physicians & Surgeons of Columbia University

  • Radiation Biologist, Radiation Oncology and Radiology Services, The Presbyterian Hospital of New York

   Current Research  

Eric Hall concentrates on two principal objectives, both of which require an understanding of the basic biology of the interaction of radiation on living cells. These are: First, research into mechanisms of the carcinogenic and mutagenic effects of low doses of radiation and; and Second, research in support of radiation therapy.

The first objective is aimed toward understanding the deleterious effects of low doses of radiation. We are constantly exposed to low level of radiation, from natural sources such as radon, to man-made sources including nuclear power and medical x-rays. Present risk estimates are based on data from the survivors of Hiroshima and Nagasaki, who were exposed to large doses at high dose-rate. The extrapolation of risk estimates to environmental situations requires an understanding of basic mechanisms of radiation carcinogenesis. Our research efforts have focused on the use of the single particle microbeam to investigate mutation and oncogenic transformation in cells of human origin resulting from the passage of a single charged particle.

The second objective is directed toward improvements in the use of radiotherapy for the treatment of cancer. Rather more than half of all cancer patients receive radiotherapy at some stage in the management of their disease. Translational research include initiatives in low dose-rate and pulsed brachytherapy, the interaction of x-rays with paclitaxel, studies of the genetic control of radiosensitivity as it relates to patients who suffer late effects from radiation treatment, and clinical trials of new protocols.

   Educational Projects  

Supported by a grant from the Radiological Society of North America, Dr. Hall in collaboration with David Brenner and Carl Elliston has introduced a web based training program for residents in Radiology. The topic is changed each month and consists of a series of questions, followed by an essay to explain and justify the answers. The course is called WEB-RAD-TRAIN, and can be accessed at: http://www.web-rad-train.org.

Dr. Hall is the author of five books. The best known is "Radiobiology for the Radiologist," now in its 6th edition, which is used by residents in Radiology and Radiation Oncology preparing for board certification. He has authored two books on radiation for the lay person, "Radiation and life" (translated into French, Arabic and Russian), as well as "Making the Radiation Therapy Decision" (with Dr. David Brenner).

Additionally, he has published over 350 papers in the peer review scientific literature. He has been awarded the Gold Medal of the Radiological Society of North America, the Gold Medal of the American Society of Therapeutic Radiology & Oncology, the Failla Award of the Radiation Research Society, and the Janeway Medal of the American Radium Society.

   Curriculum Vitae  

Click here to download a full CV (requires Adobe Acrobat Reader, available for free download here: )

   Select Publications Online  

Some papers are available online in PDF format (requires Adobe Acrobat Reader, available for free download at the above link).

If you do not find what you are looking for below, try searching for Eric Hall on PubMed

  • Persaud R, Zhou H, Hei TK and Hall EJ. Demonstration of a radiation-induced bystander effect for low dose low LET beta-particles. Radiat Environ Biophys, (2007). [abstract] [PDF 381 KB]

  • Hall EJ. Cancer caused by x-rays--a random event? Lancet Oncol 8:369-370 (2007). Reflection and reaction. No abstract available. [PDF 62 KB]

  • Smilenov LB, Hall EJ, Bonner WM and Sedelnikova OA. A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts. Radiat Prot Dosimetry 122:256-9, (2006). [abstract] [PDF 198 KB]

  • Hall EJ, Worgul BV, Smilenov L, Elliston CD and Brenner DJ. The relative biological effectiveness of densely ionizing heavy-ion radiation for inducing ocular cataracts in wild type versus mice heterozygous for the ATM gene. Radiat Environ Biophys 45:99-104, (2006). [abstract] [PDF 410 KB]

  • Hall EJ. Antiprotons for radiotherapy? Radiother Oncol. 81:231-2 (2006). No abstract available. [PDF 136 KB]

  • Hall EJ. The inaugural Frank Ellis Lecture--latrogenic cancer: the impact of intensity-modulated radiotherapy. Clin Oncol (R Coll Radiol) 18:277-82, (2006). [abstract]

  • Hall EJ. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys 65:1-7, (2006). [abstract] [PDF 520 KB]

  • Persaud R, Zhou H, Baker SE, Hei TK and Hall EJ. Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model. Cancer Res 65:9876-82, (2005).[abstract] [PDF 378 KB]

  • Hall EJ. Multiple gene effects in radiation oncogenesis. Radiat Res 163:697-8, (2005).

  • Worgul BV, Smilenov L, Brenner DJ, Vazquez M and Hall EJ. Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes. Adv Space Res 35:254-9, (2005). [abstract] [PDF 155 KB]

  • Smilenov LB, Lieberman HB, Mitchell SA, Baker RA, Hopkins KM and Hall EJ. Combined haploinsufficiency for ATM and RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair dynamics. Cancer Res 65:933-8, (2005). [abstract] [PDF 227 KB]

  • Hall EJ, Brenner DJ, Worgul B and Smilenov L. Genetic susceptibility to radiation. Adv Space Res 35:249-53, (2005). [abstract] [PDF 164 KB]

  • Hall EJ. Dose-painting by numbers: a feasible approach? Lancet Oncol 6:66 (2005). Reflection and reaction. No abstract available. [PDF 34 KB]

  • Ponnaiya B, Jenkins-Baker G, Brenner DJ, Hall EJ, Randers-Pehrson G and Geard CR. Biological responses in known bystander cells relative to known microbeam-irradiated cells. Radiat Res 162:426-32, (2004). [abstract] [PDF 149 KB]

  • Mitchell SA, Marino SA, Brenner DJ and Hall EJ. Bystander effect and adaptive response in C3H 10T(1/2) cells. Int J Radiat Biol 80:465-72, (2004). [abstract]

  • Mitchell SA, Randers-Pehrson G, Brenner DJ and Hall EJ. The bystander response in C3H 10T1/2 cells: the influence of cell-to-cell contact. Radiat Res 161:397-401, (2004). [abstract] [PDF 92 KB]

  • Hall EJ. Henry S. Kaplan Distinguished Scientist Award 2003. The crooked shall be made straight; dose-response relationships for carcinogenesis. Int J Radiat Biol 80:327-337 (2004). Review. [abstract] [PDF 423 KB]

  • Brenner DJ, Doll R, Goodhead DT, Hall EJ, Land CE, Little JB, Lubin JH, Preston DL, Preston RJ, Puskin JS, Ron E, Sachs RK, Samet JM, Setlow RB and Zaider M. Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know. Proc Natl Acad Sci USA 100:13761-13766 (2003). Epub 2003 Nov 10. [abstract] [PDF 328 KB]

  • Hall EJ and Hei TK. Genomic instability and bystander effects induced by high-LET radiation. Oncogene 22:7034-7042 (2003). Review. [abstract] [PDF 390 KB]

  • Hall EJ and Wuu CS. Radiation-induced second cancers: The impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys 56:83-88 (2003). Review. [abstract] [PDF 92 KB]

  • Brenner DJ and Hall EJ. Mortality patterns in British and US radiologists: What can we really conclude? Br J Radiol 76:1-2 (2003). Commentary. [PDF 42 KB]

  • Worgul BV, Smilenov L, Brenner DJ, Junk A, Zhou W and Hall EJ. Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts. Proc Natl Acad Sci USA 99:9836-9839 (2002). Epub 2002 Jul 15. [abstract] [PDF 158 KB]

  • Smilenov LB, Brenner DJ and Hall EJ. Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells. Cancer Res 61:5710-5713 (2001). [abstract] [PDF 61 KB]

  • Sawant SG, Randers-Pehrson G, Metting N and Hall EJ. Adaptive response and the bystander effect Induced by radiation in C3H 10T(1/2) cells in culture. Radiat Res 156:177-180 (2001). [abstract] [PDF 75 KB]

  • Sawant SG, Randers-Pehrson G, Geard CR, Brenner DJ and Hall EJ. The bystander effect in radiation oncogenesis: I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat Res 155:397-401 (2001). [abstract] [PDF 138 KB]

  • Suzuki M, Piao C, Hall EJ and Hei TK. Cell killing and chromatid damage in primary human bronchial epithelial cells irradiated with accelerated 56Fe ions. Radiat Res 155:432-439 (2001). [abstract] [PDF 107 KB]

  • Zhao YL, Piao CQ, Hall EJ and Hei TK. Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells. Radiat Res 155:230-234 (2001). [abstract] [PDF 134 KB]

  • Brenner DJ, Curtis RE, Hall EJ and Ron E. Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery. Cancer 88:398-406 (2000). [abstract] [PDF 116 KB]

  • Hall EJ. Invited editorial: CT scanning; risk versus benefit. J Radiol Prot 20:347-348 (2000). [abstract]

  • Hall EJ. Radiation, the two-edged sword: cancer risks at high and low doses. Cancer J. 6:343-350 (2000). [abstract]

  • Hall EJ. A radiation biologist looks to the future. Int J Radiat Oncol Biol Phys 46:1-2 (2000). [abstract] [PDF 34 KB]

  • Miller RC, Marino SA, Napoli J, Shah H, Hall EJ, Geard CR and Brenner DJ. Oncogenic transformation in C3H10T1/2 cells by low-energy neutrons. Int J Radiat Biol 76:327-333 (2000). [abstract] [PDF 191 KB]

  • Zhou H, Randers-Pehrson G, Waldren CA, Vannais D, Hall EJ and Hei TK. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc Natl Acad Sci97:2099-2104 (2000). [abstract] [PDF 117 KB]

  • Brenner DJ and Hall EJ. Fractionation and protraction for radiotherapy of prostate carcinoma. Int J Radiat Oncol Biol Phys 43:1095-1101 (1999). [abstract] [PDF 97 KB]

  • Hall E.J., Miller R.C. and Brenner D.J. Radiobiological principles in intravascular irradiation. Cardiovascular Radiation Medicine 1:42-47 (1999). [abstract] [PDF 352 KB]

  • Miller RC, Randers-Pehrson G, Geard CR, Hall EJ and Brenner DJ. The oncogenic transforming potential of the passage of single a particles through mammalian cell nuclei. Proc Natl Acad Sci 96:19-22 (1999). [abstract] [PDF 158 KB]

  • Miller RC, Marino SA, Martin SG, Komatsu K, Geard CR, Brenner DJ and Hall EJ. Neutron-energy-dependent cell survival and oncogenic transformation. J Radiat Res (Tokyo)  40 Suppl:53-59 (1999). [abstract]

  • Murphy RC, Berdon WE, Ruzal-Shapiro C, Hall EJ, Kornecki A, Daneman A, Brunelle F and Campbell JB. Malignancies in pediatric patients with ataxia telangiectasia. Pediatr Radiol 29:225-230 (1999). [abstract] [PDF 435 KB]

  • Rakovitch E, Mellado W, Hall EJ, Pandita TK, Sawant S and Geard CR. Paclitaxel sensitivity correlates with p53 status and DNA fragmentation, but not G2/M accumulation. Int J Radiat Oncol Biol Phys 44:1119-1124 (1999). [abstract] [PDF 239 KB]

  • Smith LG, Miller RC, Richards M, Brenner DJ and Hall EJ. Investigation of hypersensitivity to fractionated low-dose radiation exposure. Int J Radiat Oncol Biol Phys 45:187-191 (1999). [abstract] [PDF 97 KB]

  • Hall EJ. From chimney sweeps to astronauts: cancer risks in the work place: The 1998 Lauriston Taylor Lecture. Health Physics 75:357-366 (1998). [abstract]

  • Hall EJ, Schiff PB, Hanks GE, Brenner DJ, Russo J, Chen J, Sawant SG and Pandita TK. A Preliminary Report: Frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy. Cancer J Sci Am 4:385-389 (1998). [abstract]

  • Brenner DJ, Schiff PB, Huang Y and Hall EJ. Pulsed-dose-rate brachytherapy: design of convenient (daytime-only) schedules. Int J Radiat Oncol Biol Phys 39:809-815 (1997). [abstract] [PDF 599 KB]

  • Chen CZ, Huang Y, Hall EJ and Brenner DJ. Pulsed brachytherapy as a substitute for continuous low dose rate: an in vitro study with human carcinoma cells. Int. J. Radiat Oncol Biol Phys 37:137-143 (1997). [abstract] [PDF 454 KB]

  • Hall EJ. What will molecular biology contribute to our understanding of radiation-induced cell killing and carcinogenesis? Int J Radiat Biol 71:667-674 (1997). [abstract] [PDF 380 KB]

  • Hall EJ and Brenner DJ. Pulsed dose-rate brachytherapy. Radiother Oncol 45:1-2 (1997). [abstract]

  • Brenner DJ, Miller RC and Hall EJ. The radiobiology of intravascular irradiation. Int J Radiat Oncol Biol Phys 36:805-810 (1996). [abstract] [PDF 480 KB]

  • Hall EJ. Molecular Biology in Radiation Therapy: The Potential impact of recombinant technology on clinical practice. Int J Radiat Oncol Biol Phys 30:1019-1028 (1994). [abstract]

  • Hall EJ. The Janeway Lecture 1992. Nine decades of radiobiology: Is radiation therapy any the better for it? Reprinted from Cancer 71:3753-3766 (1993). [abstract]

  • Hall EJ. The gene as theme in the paradigm of cancer. The British Journal of Radiology 66:1-11 (1993). [abstract]

  • Hall EJ. Failla Memorial Lecture; From beans to genes - back to the future. Radiation Research 129:235-249 (1992). [abstract]

  • Hall EJ. From chimney sweeps to oncogenes: The quest for the causes of cancer. 1990 Annual Oration. Radiology 179:297-306 (1991). [abstract]

  • Hall EJ. The dose-rate factor in radiation biology, Weiss Lecture. Int J Radiat Biol 59:595-610 (1991). [abstract]

 

Updated 01/04/08

 

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