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This is our most recent published annual report. The complete 2009 annual
report can be downloaded as a PDF
as can individual sections of this report from the links below. Individual
studies can be browsed as HTML.
For annual reports from previous years click here.
Microbeam Development and Experimental Studies [PDF]
Microbeam Writing on a Cell at RARAF
Alan W Bigelow, Helen C Turner, Yanping Xu, Gerhard Randers-Pehrson and
David J Brenner
Formation of DNA Repair Foci using RARAF’s
UV Microspot Irradiator
Alan W Bigelow, Charles R Geard, Gerhard Randers-Pehrson and David J
Brenner
UV Microspot Resolution:
Columbia University Crown Logo
Alan W Bigelow, Helen C Turner, Guy Y Garty, Yanping Xu, Gerhard
Randers-Pehrson and David J Brenner
Proton Induced Soft X-ray Microbeam at
RARAF
Andrew Harken, Gerhard Randers-Pehrson and David J Brenner
Preliminary Studies of Flow-And-Shoot
Technology (FAST) for the Microbeam
Guy Garty, Michael Grad, Brian K Jones, Yanping Xu, Jie Xu, Gerhard
Randers-Pehrson, Daniel Attinger and David J Brenner
Neutron Microbeam
Yanping Xu, Gerhard Randers-Pehrson, Stephen A Marino and David J
Brenner
Simultaneous Immersion Mirau Interferometry
Oleksandra V Lyulko, Gerhard Randers-Pehrson and David J Brenner
Microbeam Induced Stress Response in
the C elegans Nematode
Antonella Bertucci, Roger D J Pocock, Guy Garty and David J Brenner
Bystander Studies [PDF]
Radiation-induced Bystander Signaling Pathways
in Human Skin Fibroblasts: A Role for ATM and IL-33 in the Signal
Transmission
Vladimir N Ivanov, Hongning Zhou, Shanaz A Ghandhi, Sally A Amundson
and Tom K Hei
Mutations in Succinate Dehydrogenase Subunit C
Increase Radiosensitivity and Bystander Responses
Hongning Zhou and Tom K Hei
Role of Bystander Cells after Irradiation with
a Low a Dose of Alpha Particles
Alexandre V Mezentsev and Sally A Amundson
Cell Communication Is a Significant Component
of the Early Gene Expression Response in Bystanders
Shanaz A Ghandhi and Sally A Amundson
Induction of Bystander Responses by Si490 Ions
Brian Ponnaiya, Masao Suzuki, Chirzuru Tsuruoka, Yukio Uchihori and
Tom K Hei
Genomic Instability in Single Cell Derived
Clones Following Exposure to Si490 Ions
Brian Ponnaiya, Tom K Hei and Charles R Geard
Molecular Studies [PDF]
DNMT1 Knockdown in Prostate Cancer Cells
Reduces HRAD9 Expression and Tumor Formation in Nude Mice
Aiping Zhu, Xiangyuan Wang and Howard B Lieberman
DNMT3B siRNA Downregulates HRAD9 Expression in
Prostate Cancer Cells
Corinne Leloup, Aiping Zhu and Howard B Lieberman
Radiosensitivity to High Energy Iron Ions is
Influenced by Heterozygosity for ATM, RAD9 and BRCA1
Lubomir B Smilenov, Guangming Zhou, Howard B Lieberman, Thomas Ludwig
and Eric J Hall
Transforming Growth Factor-β Induced Protein (TGFBI)
Suppresses Mesothelioma Progression through the Akt/mTOR Pathway
Gengyun Wen, Mei Hong, Bingyan Li, Michael A Partridge, Burong Hu,
Gloria M Calaf and Tom K Hei
TGFBI Deficiency Leads to Aberrant CREB and
Cyclin D1 Activations by Enhanced Protein Kinase an Activity
Ping Lu, Ye Zhang, Tom K Hei and Yongliang Zhao
Alterations in Gene Expression Levels in
Individual Cells in Response to Ionizing Radiation
Brian Ponnaiya, Sally A Amundson, Shanaz A Ghandhi, Lubomir B
Smilenov, Charles R Geard and David J Brenner
Histone Gene Expression in Irradiated Cells
Jarah A Meador and Sally A Amundson
DNA Repair in Human Adipose Tissue-derived
Stem Cells
Jarah A Meador and Adayabalam S Balajee
Hypoxia-Induced Radioresistance is Associated
with 53BP1 Upregulation and Facilitated Turnover
Alexander V Kofman, Jarah A Meador and Charles R Geard
Mitochondria-derived Reactive Intermediate
Species Mediate Asbestos-induced Nuclear DNA Mutagenesis and Oxidative
Stress-Responsive Signaling Pathways
Sarah XL Huang, Michael A Partridge, Shanaz A Ghandhi, Evelyn
Hernandez-Rosa, Mercy M Davidson, Sally A Amundson, Sindu Krishna and
Tom K Hei
Asbestos Induces Mitochondrial DNA Mutation
and Functional Alteration: Potential Source of Intracellular Oxidants
and Implications for Mechanism of Mutagenicity
Sarah XL Huang, Michael A Partridge, Evelyn Hernandez-Rosa, Mercy M
Davidson and Tom K Hei
Cellular Studies [PDF]
Human Endothelial Cells in 3D Model Vessel
Systems: Differential Effects of High and Low LET Space Radiations
Peter Grabham, Burong Hu, Preety Sharma and Charles R Geard
Catechol Estrogen as a Biomarker for Mammary
Gland Cancer
Gloria M Calaf and Fernando Garrido
Population-Based Radiology or Radiotherapy Oriented
Studies [PDF]
Cancer Risks after Radiation Exposure in
Middle Age: Mechanisms and Societal Implications
Igor Shuryak, Rainer K Sachs and David J Brenner
A Model of Interactions between
Radiation-Induced Oxidative Stress, Protein and DNA Damage in
Deinococcus Radiodurans
Igor Shuryak and David J Brenner
Radiation Dose Measurements in Phantom from
Coronary CT Angiography Performed with First Generation Volume Scanner
Carl D Elliston, Andrew J Einstein, Andrew E Arai, Marcus Y Chen,
Rich Mather, Gregory D Pearson, Robert L DeLaPaz, Edward L Nickoloff,
Ajoy Dutta and David J Brenner
Center for High-Throughput Minimally-Invasive Radiation
Biodosimetry (U19) [PDF]
The Columbia Center for High-Throughput
Minimally-Invasive Radiation Biodosimetry
David J Brenner
High-Throughput mBAND
Alan W Bigelow, Guy Y Garty, Antonella Bertucci, Charles R Geard and
David J Brenner
Evaluation of Effect of Genotoxic Drugs on
Peripheral Blood Gene Expression Profiling for Radiation Biodosimetry
with Cancer Patients
Sunirmal Paul and Sally A Amundson
Optimizing the γ-H2AX Assay for High
Throughput Automated Biodosimetry
Helen C Turner, David J Brenner, Youhua Chen, Antonella Bertucci,
Jian Zhang, Hongliang Wang, Oleksandra V Lyulko, Yanping Xu, Julia
Schäfer, Nabil Simaan, Gerhard Randers-Pehrson, Y Lawrence Yao, Sally A
Amundson and Guy Garty
An Online PC Cluster for High Performance
Computing of Bio-Physics Project
Yanping Xu and Helen C Turner
Upgrades to Rapid Automated Biodosimetry
Technology (RABIT)
Youhua Chen, Jian Zhang, Hongliang Wang, Guy Garty, Gary W Johnson,
Nabil Simaan, Y Lawrence Yao and David J Brenner
A Rapid Autofocus System for High Speed
Imaging
Guy Garty, Nina Bahar, Gerhard Randers-Pehrson and David J Brenner
Automated Image Analysis for Micronuclei Assay
in RABIT
Oleksandra V Lyulko, Guy Garty, Helen C Turner, Gerhard
Randers-Pehrson and David J Brenner
Development of a Button-Type Personal
Dosimeter
Stephen A Marino, Gary W Johnson and David J Brenner
The Radiological Research Accelerator Facility an NIH-Supported
Resource Center [PDF]
Dir., David J. Brenner, PhD, DSc; Assoc. Dir. Gerhard Randers-Pehrson,
PhD; Mnger., Stephen A. Marino, MS |
